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Experimental study on the antibacterial effects of zirconium phosphate gauze loaded with silver
Objective To investigate the antibacterial effects of zirconium phosphate gauze loaded with silver on rat burn wounds seeded with commonly seen bacteria.
Methods
Wistar rats were employed in the study and were scalded and infected. The minimum inhibition concentration f MIC 1 and minimum bactericidal concentration(MBC)of zirconium phosphate loaded with silver were determined by double dilution in tubes. The effect on wound healing and the subeschar bacterial count of the rat burn wounds were observed after the wounds had been covered by gauze loaded with zirconium phosphate and silver. And also with the gauze which has been rinsed fi)r 20 times.
Results
The MIC of silver joa：ed zirconium phosphate on Staphylococ(!us aureus, Pseudomonas aeruginosa and E．coli were 8, 8 and 16 mg／L, respectively, while the MBC were l 6.8 and 32 mg/L respectively. The subeschar bacterial count in the burn wounds with the gauze with silver loaded zirconium phosphate was ten times lower than that in those which were treated with gauze with SD—Ag and l 00 times lower than that with ordinary gauze. But there was no difference in the bacterial COUnt between the wounds which were treated with fresh gauze with silver loaded zirconium phosphate and that with the gauze which has been rinsed for 20 times(P>0.05). Furthermore, wound healing seemed to be better with the gauze with silver loaded zirconium phosphate when compared with those by the other two kinds of gauze.
Conclusion
The silver loaded zirconium phosphate was found to be bacteriocidal against bacteria commonly seen in the burn wounds.
Methods
Wistar rats were employed in the study and were scalded and infected. The minimum inhibition concentration f MIC 1 and minimum bactericidal concentration(MBC)of zirconium phosphate loaded with silver were determined by double dilution in tubes. The effect on wound healing and the subeschar bacterial count of the rat burn wounds were observed after the wounds had been covered by gauze loaded with zirconium phosphate and silver. And also with the gauze which has been rinsed fi)r 20 times.
Results
The MIC of silver joa：ed zirconium phosphate on Staphylococ(!us aureus, Pseudomonas aeruginosa and E．coli were 8, 8 and 16 mg／L, respectively, while the MBC were l 6.8 and 32 mg/L respectively. The subeschar bacterial count in the burn wounds with the gauze with silver loaded zirconium phosphate was ten times lower than that in those which were treated with gauze with SD—Ag and l 00 times lower than that with ordinary gauze. But there was no difference in the bacterial COUnt between the wounds which were treated with fresh gauze with silver loaded zirconium phosphate and that with the gauze which has been rinsed for 20 times(P>0.05). Furthermore, wound healing seemed to be better with the gauze with silver loaded zirconium phosphate when compared with those by the other two kinds of gauze.
Conclusion
The silver loaded zirconium phosphate was found to be bacteriocidal against bacteria commonly seen in the burn wounds.
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